Breast Cancer Genetics Research Paper

Instructions:

Write a 4-5 page genetics research paper (not counting cover and reference pages) over a specific type of cancer. The main emphasis of your paper must focus on genetic aspects concerning the cancer. A written abstract is not required for this assignment.

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Closely follow the outline (below) and grading rubric to construct and organize your paper:

Introduction (0.5 – 1 page)

Introduce the cancer you have chosen by providing basic background information.
General statistics of the cancer: Don’t go into too much detail. Simply mention a few facts to display the impact this cancer has on society.
Incidence rates of this cancer
Mortality rate or common outcomes for the cancer
The demographics of those at higher risk (if applicable)
Body (3 pages)

Present the common genetic abnormalities (mutations/epigenomic change) observed in the cancer and discuss their roles in cancer development? Be sure to research all of the following topics:
Tumor suppressor genes (e.g., p53, Retinoblastoma gene or Rb)
Oncogenes (e.g., ras, HER2/neu, myc)
DNA repair genes
MicroRNAs
Gene expression changes
Chromosomal alterations
Other genomic targets (e.g., SNPs, DNA methylation) or syndromes (e.g., Lynch, Li Fraumeni, etc.) that are involved in the increased risk and/or development of the cancer.
Discuss any existing or potential genetically related diagnostic and therapeutic options.
Research genetically-based diagnostic tests or other genetic screening methods used to identify the genetic abnormalities that you’ve previously discussed.
Investigate the following potential therapies as they relate to the cancer:
stem cell therapy
gene therapy
genome editing therapy (e.g. CRISPR)
immunotherapy
Conclusion (0.5 – 1 page)

Analyze the content against a biblical worldview.
*It is expected that you research your topic by examining at least 2 major sources other than the textbook. Write the paper in Microsoft Word and format it according to APA standards (exception – abstract is not required).

The sources must be from NCBI and Pubmed that are no older than 2015 and the biblical worldview should contain scripture references to support the conclusion. It would be best to use the resources I have used in my PowerPoint as well, but to also include the NCBI and Pubmed sources as well to support the material.

 

I have included the PowerPoint that I have made that is an outline of my paper. My paper should answer these questions that my PowerPoint does not include an answer to these questions. What about epigenetics? What pathways are altered due to genetic and epigenetic alterations? What are the actual screening assays and how are they done? We all have the BRACA genes so what are they actually looking for? Any other potential interventional therapies or current ongoing clinical trials? How do the interventions actually work, how do they impair angiogenesis, how do they stop cell growth, which receptors are blocked, etc.?

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